Endocrine Abstracts

We have investigated the effects of estradiol valerat plus dienogest and raloxifene on serum high sensitive C - reactive protein (hsCRP) levels in healthy postmenopausal women. This study was approved by the local ethics committee. Forty eight healthy postmenopausal women were randomly divided into three groups. While group I (n=16) was given 60 mg raloxifene, group II (n=16) received continuously 2 mg estradiol valerat plus 2 mg dienogest. Group III (n=16) received no medicat...

Objective: Thiazolidinediones offer promise as oral insulin-sensitizing agents. Peroxisome proliferator-activated receptor-g (PPARg), a member of the steroid receptor superfamily, play a pivotal role in the differentiation of adipocytic cells. Osteoblasts and adipocytes are derived from common bone marrow stromal cells that play crucial roles in the generation of osteoclasts. Activation of peroxisome proliferator-activated receptor-g (PPARg) induces adipogenic differentiation ...

Nebivolol is a recently developed beta(1)-selective adrenergic receptor antagonist with proposed nitric oxide mediated vasodilating properties. Effect of nebivolol on vascular smooth muscle has been attributed to estrogen receptor-mediated vascular responsiveness. Although it is known that nitric oxide has relaxing effect on myometrium, there is no report whether nebivolol application affect myometrial contractility. Therefore, we have investigated the effect of nebivolol on r...

Raloxifene is a new selective estrogen modulator. It has been shown to prevent bone loss and to reduce vertebral fracture risk in postmenopausal women. This study was designed to investigate effects of raloxifene and oestradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups: Controls subcutaneously received saline alone. Raloxifene (2 mg/kg) and oestradiol (30 m...

Polychlorinated biphenyls (PCBs) are persistent environmental pollutants. Two industrial PCB mixtures, Aroclors 1221 and 1254 have been suggested to have estrogenic and anti-estrogenic properties, respectively. We have examined whether these PCB mixtures modulated bone formation and resorption in intact and ovariectomized (ovx) rat models. Twentyfour adult female rats were divided into three groups subcutaneously receiving 4% DMSO (Control), Aroclor 1221 (10 mg/kg) and Aroclor...

Brain catecholaminergic neurotransmitters are involved in the regulation of food intake. Increased dopamin and noradrenaline release in the lateral hypothalamic area (LHA) results in inhibition of food intake whereas stimulative effects have been reported in the medial nucleus. Elevated noradrenaline levels have been shown in the hypothalamus and nucleus accumbens (NAC) of hyperphagic-hypermetabolic rats. Effects of melatonin on food intake in various species have been controv...

Leptin, which is secreted mainly by adipocytes and some other tissues including pituitary, informs the brain about the mass of adipose tissue and has an important role in energy homeostasis. We have previously shown that melatonin decreases circulating leptin levels. Whether melatonin has an effect on leptin synthesis in pituitary is currently unknown. Therefore, the aim of this study was to immunohistochemically examine the effects of pinealectomy and administration of melato...

Effects of paint thinner inhalation on serum testosterone synthesis and secretion were investigated in the male rat. A control group inhaled normal air ventilation. The remaining animals were divided into three groups and exposed to paint thinner in a glassy cage for 15 and 30 days. A group of animals was allowed to recover for 15 day after 30 days of exposure. Toluene concentration (the largest constituent in thinner, 66%) was set at 1500 ppm in the inhalation air. At the end...

This study was undertaken to examine the effects of leptin on testicular histology in mice. Animals were divided into two groups. Group I served as controls. Mice in Group II were injected daily with leptin for five days. All animals were killed by decapitation at the end of the experiment. The testes were removed and weighed out. Some of the testicular tissue specimens were used for light and electron microscopic examination. The remaining samples were processed for semiquant...

Objective: Estrogen or raloxifen prevent estrogen deficiency-induced bone loss animals and humans. There is a medical need for agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects tissue. So, we investigated the effects of raloxifen on bone strength and cholesterol levels in osteoporotic rats and compared them with estrogen treatment.Methods: Thirty-one ovariectomized (OVX) Sprague-Dawney ra...